Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13634415 | 0.79 | KEAP1 (0.52) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL3919692 | 0.79 | HDAC1 (0.51) | KEAP1NFE2L2CA2ALDH1A1PTGS2 | |
| SCHEMBL13164002 | 0.79 | KEAP1 (0.57) | KEAP1NFE2L2CA2ALDH1A1ALOX12 | |
| SCHEMBL13164003 | 0.77 | KEAP1 (0.50) | KEAP1NFE2L2ALDH1A1ALOX12HTT | |
| SCHEMBL8778823 | 0.77 | KEAP1 (0.59) | KEAP1NFE2L2ALDH1A1HTTLMNA | |
| SCHEMBL9102994 | 0.77 | KEAP1 (0.59) | KEAP1NFE2L2ALDH1A1HTTLMNA | |
| SCHEMBL9099317 | 0.77 | KEAP1 (0.59) | KEAP1NFE2L2ALDH1A1HTTLMNA | |
| SCHEMBL8778811 | 0.77 | KEAP1 (0.59) | KEAP1NFE2L2ALDH1A1HTTLMNA | |
| SCHEMBL9101224 | 0.77 | KEAP1 (0.59) | KEAP1NFE2L2ALDH1A1HTTLMNA | |
| SCHEMBL3683856 | 0.77 | KEAP1 (0.59) | KEAP1NFE2L2ALDH1A1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2206707-B1 | AZOLECARBOXAMIDE COMPOUND OR SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2014-07-23 | — | — | EP | disclosed |
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |