SCHEMBL13639233

SCHEMBL13639233

COc1cc(-c2n[nH]c(=S)n2-c2cccc3ccccc23)c(OC)cc1O

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.62
HSP90AB1 P08238 1/20 0.62
SMN1; SMN2 Q16637 5/20 0.56
GAA P10253 3/20 0.56
L3MBTL1 Q9Y468 3/20 0.56
MAPT P10636 3/20 0.56
TDP1 Q9NUW8 2/20 0.56
ALDH1A1 P00352 12/20 0.51
HPGD P15428 7/20 0.51
POLB P06746 3/20 0.51
KDM4E B2RXH2 4/20 0.49
MEN1 O00255 3/20 0.49
KMT2A Q03164 3/20 0.49
USP2 O75604 1/20 0.49
BLM P54132 1/20 0.49
APOBEC3G Q9HC16 2/20 0.49
GFER P55789 3/20 0.46
HSD17B10 Q99714 2/20 0.46
LMNA P02545 1/20 0.46
PRNP P04156 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8931074 0.95 HSP90AA1 (0.63) HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1
SCHEMBL14293443 0.85 HSP90AA1 (0.59) HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1
SCHEMBL8930543 0.84 HSP90AA1 (0.78) HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1
SCHEMBL8930974 0.84 MAPT (0.65) HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1
SCHEMBL8931103 0.82 HSP90AA1 (0.62) HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1
SCHEMBL8930669 0.81 HSP90AA1 (0.62) HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1
SCHEMBL8930147 0.81 HSP90AA1 (0.64) HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1
SCHEMBL13983415 0.80 HSP90AA1 (0.61) HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1
SCHEMBL8930897 0.80 HSP90AA1 (0.69) HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1
SCHEMBL12637565 0.79 HSP90AA1 (0.58) HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1817295-B1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY SYNTA PHARMACEUTICALS CORP (US) 2012-11-07 EP disclosed