Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PRNP | P04156 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.51 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8930974 | 0.90 | MAPT (0.65) | HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL13639233 | 0.85 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL8931074 | 0.83 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL13983482 | 0.82 | GAA (0.66) | HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL8930543 | 0.81 | HSP90AA1 (0.78) | HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL14344996 | 0.78 | ALDH1A1 (0.62) | HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL8931024 | 0.78 | SMN1; SMN2 (0.56) | HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL8930993 | 0.78 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL13983420 | 0.77 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL13983089 | 0.77 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1SMN1; SMN2GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021364-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2008-02-21 | — | — | WO | disclosed |