Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL6 | P05231 | 8/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4147740 | 0.94 | IL6 (0.53) | IL6NPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4135792 | 0.86 | IL6 (0.72) | IL6NPC1KMT2AMEN1CASP3 | |
| SCHEMBL4132008 | 0.83 | IL6 (0.51) | IL6NPC1KMT2AMEN1CASP3 | |
| SCHEMBL4582436 | 0.83 | IL6 (0.51) | IL6NPC1KMT2AMEN1CASP3 | |
| SCHEMBL4581594 | 0.82 | IL6 (0.73) | IL6KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL4147183 | 0.81 | IL6 (0.50) | IL6KDM4EPDCD1CD274ALDH1A1 | |
| SCHEMBL13639299 | 0.81 | IL6 (0.49) | IL6NPC1KMT2AMEN1CASP3 | |
| SCHEMBL4580854 | 0.81 | IL6 (0.71) | IL6KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL4143840 | 0.81 | IL6 (0.55) | IL6NPC1KMT2AMEN1CASP3 | |
| SCHEMBL4145235 | 0.80 | IL6 (0.37) | IL6NPC1KMT2AMEN1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1995242-B1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-11-07 | — | — | EP | disclosed |