Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL6 | P05231 | 8/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
| ▸ | MPO | P05164 | 1/20 | 0.30 |
| ▸ | TPO | P07202 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14015566 | 0.91 | IL6 (0.58) | IL6 | |
| SCHEMBL13639302 | 0.88 | IL6 (0.49) | IL6HTR2AHTR2CHTR2BLMNA | |
| SCHEMBL14015569 | 0.87 | IL6 (0.55) | IL6 | |
| SCHEMBL14015805 | 0.86 | IL6 (0.47) | IL6HTR2AHTR2CHTR2BLMNA | |
| SCHEMBL4580973 | 0.81 | IL6 (0.55) | IL6HTR2AHTR2CHTR2BNPSR1 | |
| SCHEMBL4581997 | 0.80 | IL6 (0.51) | IL6HTR2AHTR2CHTR2BLMNA | |
| SCHEMBL4582972 | 0.80 | IL6 (0.53) | IL6LMNA | |
| SCHEMBL4132828 | 0.79 | IL6 (0.59) | IL6HTR2AHTR2CHTR2BLMNA | |
| SCHEMBL4581076 | 0.79 | IL6 (0.53) | IL6LMNAGLAMAPT | |
| SCHEMBL4581517 | 0.79 | IL6 (0.51) | IL6LMNANPSR1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1995242-B1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-11-07 | — | — | EP | disclosed |
| EP-1995242-A1 | NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY | Santen Pharmaceutical Co., Ltd (JP) | 2008-11-26 | — | — | EP | disclosed |