Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 17/20 | 0.49 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.49 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8258975 | 0.90 | MAOB (0.46) | PARP1PARP2CDK12CDK1CDK2 | |
| SCHEMBL1202261 | 0.90 | MAOB (0.51) | PARP1MAOBADORA2AADORA2BADORA1 | |
| SCHEMBL1202315 | 0.87 | RIPK1 (0.52) | PARP1CDK1MAOBADORA2AADORA2B | |
| SCHEMBL1201636 | 0.86 | MAOB (0.49) | MAOBADORA2AADORA2BADORA1 | |
| SCHEMBL1201787 | 0.84 | MAOB (0.43) | MAOBADORA2AADORA2BADORA1 | |
| SCHEMBL1201879 | 0.84 | MAOB (0.43) | PARP1MAOBADORA2AADORA2BADORA1 | |
| SCHEMBL1200591 | 0.84 | NPC1 (0.48) | MAOBADORA2AADORA2BADORA1 | |
| SCHEMBL1201507 | 0.83 | NPC1 (0.43) | MAOBADORA2AADORA2BADORA1 | |
| SCHEMBL1200784 | 0.83 | MAOB (0.43) | PARP1PARP2CDK12MAOBADORA2A | |
| SCHEMBL1201732 | 0.83 | HRH4 (0.41) | PARP1PARP2CDK12CDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863771-B1 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS B-SECRETASE INHIBITORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2012-11-07 | — | — | EP | disclosed |