Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 20/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | MDM4 | O15151 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13639652 | 1.00 | MDM2 (0.55) | MDM2TP53MDM4 | |
| SCHEMBL13639579 | 0.87 | MDM2 (0.57) | MDM2TP53MDM4 | |
| SCHEMBL13639638 | 0.87 | MDM2 (0.57) | MDM2TP53MDM4 | |
| SCHEMBL13639569 | 0.82 | MDM2 (0.39) | MDM2TP53MDM4 | |
| SCHEMBL13639599 | 0.77 | MDM2 (0.46) | MDM2TP53MDM4 | |
| SCHEMBL7950362 | 0.75 | MDM2 (0.75) | MDM2TP53MDM4 | |
| SCHEMBL7951910 | 0.74 | TP53 (0.43) | MDM2TP53 | |
| SCHEMBL7952480 | 0.73 | MDM2 (0.63) | MDM2TP53MDM4 | |
| SCHEMBL18772873 | 0.73 | MDM2 (0.59) | MDM2TP53MDM4 | |
| SCHEMBL18772871 | 0.73 | MDM2 (0.72) | MDM2TP53MDM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2340021-B1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | HOFFMANN LA ROCHE (CH) | 2012-11-07 | — | — | EP | disclosed |