Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 17/20 | 0.45 |
| ▸ | MDM4 | O15151 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13639533 | 0.84 | MDM2 (0.49) | MDM2MDM4TP53 | |
| SCHEMBL13639638 | 0.80 | MDM2 (0.57) | MDM2MDM4TP53 | |
| SCHEMBL13639579 | 0.80 | MDM2 (0.57) | MDM2MDM4TP53 | |
| SCHEMBL7954402 | 0.78 | MDM2 (0.56) | MDM2MDM4TP53 | |
| SCHEMBL13639581 | 0.74 | MDM2 (0.49) | MDM2MDM4TP53 | |
| SCHEMBL13319671 | 0.73 | MDM2 (0.70) | MDM2MDM4TP53 | |
| SCHEMBL2152034 | 0.73 | MDM2 (0.70) | MDM2MDM4TP53 | |
| SCHEMBL13316671 | 0.73 | MDM2 (0.39) | MDM2MDM4TP53 | |
| SCHEMBL18772884 | 0.70 | SLC6A2 (0.40) | MDM2TP53TAAR1 | |
| SCHEMBL13639599 | 0.70 | MDM2 (0.46) | MDM2MDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2340021-B1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | HOFFMANN LA ROCHE (CH) | 2012-11-07 | — | — | EP | disclosed |