Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 18/20 | 0.49 |
| ▸ | MDM4 | O15151 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13639638 | 0.85 | MDM2 (0.57) | MDM2MDM4TP53 | |
| SCHEMBL13639579 | 0.85 | MDM2 (0.57) | MDM2MDM4TP53 | |
| SCHEMBL13639583 | 0.84 | MDM2 (0.45) | MDM2MDM4TP53 | |
| SCHEMBL13639581 | 0.79 | MDM2 (0.49) | MDM2MDM4TP53 | |
| SCHEMBL13639574 | 0.75 | SLC9A1 (0.38) | MDM2TP53SLC6A2 | |
| SCHEMBL13639599 | 0.74 | MDM2 (0.46) | MDM2MDM4TP53 | |
| SCHEMBL7945149 | 0.74 | MDM2 (0.61) | MDM2MDM4TP53 | |
| SCHEMBL7948295 | 0.72 | MDM2 (0.61) | MDM2MDM4TP53 | |
| SCHEMBL13639535 | 0.71 | MDM2 (0.60) | MDM2MDM4TP53 | |
| SCHEMBL12445905 | 0.71 | MDM2 (0.60) | MDM2MDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2340021-B1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | HOFFMANN LA ROCHE (CH) | 2012-11-07 | — | — | EP | disclosed |