Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 12/20 | 0.31 |
| ▸ | TP53 | P04637 | 3/20 | 0.31 |
| ▸ | MDM4 | O15151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7950135 | 0.81 | MDM2 (0.40) | MDM2TP53MDM4 | |
| SCHEMBL13639600 | 0.81 | MDM2 (0.40) | MDM2TP53MDM4 | |
| SCHEMBL18773200 | 0.79 | — | — | |
| SCHEMBL7942537 | 0.75 | MDM2 (0.47) | MDM2TP53MDM4 | |
| SCHEMBL18773291 | 0.74 | — | — | |
| SCHEMBL13639641 | 0.73 | MDM2 (0.33) | MDM2TP53MDM4 | |
| SCHEMBL13639720 | 0.73 | CACNA1G (0.38) | — | |
| SCHEMBL3376570 | 0.72 | MDM2 (0.61) | MDM2TP53MDM4 | |
| SCHEMBL13571979 | 0.72 | MDM2 (0.61) | MDM2TP53MDM4 | |
| SCHEMBL3376564 | 0.72 | MDM2 (0.61) | MDM2TP53MDM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2340021-B1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | HOFFMANN LA ROCHE (CH) | 2012-11-07 | — | — | EP | disclosed |