Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 6/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15600616 | 0.84 | SMN1; SMN2 (0.62) | ALDH1A1LMNASMN1; SMN2MAOBMAOA | |
| SCHEMBL17507455 | 0.84 | ALDH1A1 (0.62) | ALDH1A1LMNASMN1; SMN2MAOBMAOA | |
| SCHEMBL12767321 | 0.84 | MAOB (0.56) | ALDH1A1LMNASMN1; SMN2MAOBMAOA | |
| SCHEMBL13982239 | 0.77 | MAOB (0.50) | ALDH1A1LMNASMN1; SMN2MAOBMAOA | |
| SCHEMBL13639940 | 0.77 | SMN1; SMN2 (0.68) | ALDH1A1LMNASMN1; SMN2MAOBSIRT2 | |
| SCHEMBL13639901 | 0.76 | SIRT2 (0.55) | ALDH1A1LMNASMN1; SMN2MAOBMAOA | |
| SCHEMBL13982232 | 0.74 | MEN1 (0.63) | ALDH1A1MAPTKDM4EMEN1GAA | |
| SCHEMBL13982287 | 0.73 | CA1 (0.61) | ALDH1A1LMNASMN1; SMN2MAOBMAOA | |
| SCHEMBL15600604 | 0.73 | CA1 (0.56) | ALDH1A1LMNASMN1; SMN2MAOBMAPT | |
| SCHEMBL12767271 | 0.72 | MEN1 (0.58) | ALDH1A1LMNASMN1; SMN2MAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2532643-A1 | IRE-1A Inhibitors | MannKind Corporation (US) | 2012-12-12 | — | — | EP | disclosed |
| EP-2520561-A1 | IRE-1A Inhibitors | MannKind Corporation (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2008154484-A1 | IRE-1A INHIBITORS | MANNKIND CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |