Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 13/20 | 0.42 |
| ▸ | CNR1 | P21554 | 4/20 | 0.41 |
| ▸ | CNR2 | P34972 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13585638 | 1.00 | BRD4 (0.45) | BRD4CHRM1CNR1CNR2 | |
| SCHEMBL13585800 | 1.00 | BRD4 (0.45) | BRD4CHRM1CNR1CNR2 | |
| SCHEMBL13585109 | 1.00 | BRD4 (0.45) | BRD4CHRM1CNR1CNR2 | |
| SCHEMBL13585641 | 1.00 | BRD4 (0.45) | BRD4CHRM1CNR1CNR2 | |
| SCHEMBL13640668 | 1.00 | BRD4 (0.45) | BRD4CHRM1CNR1CNR2 | |
| SCHEMBL13585084 | 0.93 | BRD4 (0.43) | BRD4CHRM1CNR1CNR2 | |
| SCHEMBL13640653 | 0.93 | BRD4 (0.43) | BRD4CHRM1CNR1CNR2 | |
| SCHEMBL2041586 | 0.93 | BRD4 (0.43) | BRD4CHRM1CNR1CNR2 | |
| SCHEMBL13584781 | 0.93 | BRD4 (0.43) | BRD4CHRM1CNR1CNR2 | |
| SCHEMBL13640237 | 0.93 | BRD4 (0.43) | BRD4CHRM1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509949-B1 | PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: HIV INTEGRASE INHIBITORS WITH THERAPEUTIC APPLICATIONS | UNIV GEORGIA (US) | 2014-04-23 | — | — | EP | disclosed |
| US-8703801-B2 | Pyridinone hydroxycyclopentyl carboxamides: HIV integrase inhibitors with therapeutic applications | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| US-20120282218-A1 | PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: HIV INTEGRASE INHIBITORS WITH THERAPEUTIC APPLICATIONS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC. (US) | 2012-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120282218-A1 | PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: HIV INTEGRASE INHIBITORS WITH THERAPEUTIC APPLICATIONS | PAICS, DUT, AADAC | BRD4 960/4885CHRM1 2122/4885CNR1 3744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.