Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR2 | Q969V1 | 8/20 | 0.45 |
| ▸ | DRD2 | P14416 | 6/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | BIRC3 | Q13489 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13640716 | 0.90 | MCHR2 (0.53) | MCHR2DRD2SLC6A4KCNH2HSD11B1 | |
| SCHEMBL13640789 | 0.87 | MCHR2 (0.43) | MCHR2DRD2SLC6A4KCNH2ALDH1A1 | |
| SCHEMBL13641017 | 0.87 | MCHR2 (0.43) | MCHR2DRD2SLC6A4KCNH2ALDH1A1 | |
| SCHEMBL13640896 | 0.83 | MCHR2 (0.38) | MCHR2DRD2SLC6A4KCNH2HTR2A | |
| SCHEMBL13643960 | 0.81 | MCHR2 (0.42) | MCHR2DRD2SLC6A4KCNH2ALDH1A1 | |
| SCHEMBL13640901 | 0.80 | OPRD1 (0.35) | MCHR2DRD2SLC6A4KCNH2OPRM1 | |
| SCHEMBL13640854 | 0.78 | KCNH2 (0.36) | MCHR2DRD2SLC6A4KCNH2HSD11B1 | |
| SCHEMBL12899031 | 0.78 | MCHR2 (0.41) | MCHR2DRD2SLC6A4KCNH2HTR2A | |
| SCHEMBL12989296 | 0.77 | MCHR2 (0.42) | MCHR2DRD2SLC6A4KCNH2ALDH1A1 | |
| SCHEMBL14580534 | 0.77 | MCHR2 (0.42) | MCHR2DRD2SLC6A4KCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8497295-B2 | Spiroindoline modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-30 | — | — | US | disclosed |
| US-20120283243-A1 | Spiroindoline Modulators of Muscarinic Receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283243-A1 | Spiroindoline Modulators of Muscarinic Receptors | CHRM3, CHRM2, CHRM5 | MCHR2 179/4885DRD2 491/4885SLC6A4 827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.