Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.76 |
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.76 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.76 |
| ▸ | HDAC10 | Q969S8 | 12/20 | 0.76 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.76 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.76 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.76 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.76 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.76 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.76 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.76 |
| ▸ | NAAA | Q02083 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1364426 | 1.00 | HDAC1 (0.76) | HDAC1HDAC6HDAC8HDAC10HDAC2 | |
| SCHEMBL1365042 | 0.91 | HDAC1 (0.68) | HDAC1HDAC6HDAC8HDAC10HDAC2 | |
| SCHEMBL1364875 | 0.89 | HDAC1 (0.66) | HDAC1HDAC6HDAC8HDAC10HDAC2 | |
| SCHEMBL9489804 | 0.88 | HDAC1 (0.82) | HDAC1HDAC6HDAC8HDAC10HDAC2 | |
| SCHEMBL9188890 | 0.88 | HDAC1 (0.82) | HDAC1HDAC6HDAC8HDAC10HDAC2 | |
| SCHEMBL9452844 | 0.88 | HDAC1 (0.82) | HDAC1HDAC6HDAC8HDAC10HDAC2 | |
| SCHEMBL9492235 | 0.88 | HDAC1 (0.82) | HDAC1HDAC6HDAC8HDAC10HDAC2 | |
| SCHEMBL7460068 | 0.88 | HDAC1 (0.82) | HDAC1HDAC6HDAC8HDAC10HDAC2 | |
| SCHEMBL20734829 | 0.88 | HDAC1 (0.82) | HDAC1HDAC6HDAC8HDAC10HDAC2 | |
| SCHEMBL9489756 | 0.88 | HDAC1 (0.82) | HDAC1HDAC6HDAC8HDAC10HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2258677-B1 | HISTONE DEACETYLASE INHIBITORS | UNIV GEORGETOWN (US) | 2014-06-18 | — | — | EP | disclosed |
| US-8748463-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2014-06-10 | — | — | US | disclosed |
| US-20130065963-A1 | Histone Deacetylase Inhibitors and Methods of Use Thereof | GEORGETOWN UNIVERSITY (US) | 2013-03-14 | — | — | US | disclosed |
| US-8222451-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2012-07-17 | — | — | US | disclosed |
| US-8067600-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-8067600-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-8067600-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-20110098504-A1 | Histone Deacetylase Inhibitors and Methods of Use Thereof | GEORGETOWN UNIVERSITY (US) | 2011-04-28 | — | — | US | disclosed |
| EP-2258677-A2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2010-12-08 | — | — | EP | disclosed |
| US-7842835-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2010-11-30 | — | — | US | disclosed |
| US-7507828-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2009-03-24 | — | — | US | disclosed |
| EP-1644323-A4 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | UNIV GEORGETOWN (US) | 2007-06-20 | — | — | EP | disclosed |
| EP-1794117-A2 | MERCAPTOAMIDES AS HISTONE DEACETYLASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| EP-1644323-A2 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2006028972-A2 | MERCAPTOAMIDES AS HISTONE DEACETYLASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2006-03-16 | — | — | WO | disclosed |
| WO-2006028972-A2 | MERCAPTOAMIDES AS HISTONE DEACETYLASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2006-03-16 | — | — | WO | disclosed |
| US-20060047123-A1 | Mercaptoamides as histone deacetylase inhibitors | AHMED SALEH | 2006-03-02 | — | — | US | disclosed |
| US-20050032831-A1 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY | 2005-02-10 | — | — | US | disclosed |
| WO-2005007091-A2 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2005-01-27 | — | — | WO | disclosed |
| WO-2005007091-A2 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2005-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065963-A1 | Histone Deacetylase Inhibitors and Methods of Use Thereof | HDAC5, HDAC6, HDAC1 | HDAC1 3/4885HDAC6 2/4885HDAC8 9/4885 |
| US-20050032831-A1 | Histone deacetylase inhibitors and methods of use thereof | HDAC5, HDAC6, HDAC1 | HDAC1 3/4885HDAC6 2/4885HDAC8 9/4885 |
| US-20110098504-A1 | Histone Deacetylase Inhibitors and Methods of Use Thereof | HDAC5, HDAC6, HDAC1 | HDAC1 3/4885HDAC6 2/4885HDAC8 9/4885 |
| US-20060047123-A1 | Mercaptoamides as histone deacetylase inhibitors | HDAC1, HDAC11, HDAC2 | HDAC1 1/4885HDAC6 4/4885HDAC8 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.