Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.82 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.82 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.82 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.82 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.82 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.82 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.82 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.82 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.82 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.82 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.82 |
| ▸ | NAAA | Q02083 | 1/20 | 0.82 |
| ▸ | NPC1 | O15118 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | NAMPT | P43490 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9188890 | 1.00 | HDAC1 (0.82) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL9489756 | 1.00 | HDAC1 (0.82) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL9452844 | 1.00 | HDAC1 (0.82) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL9489804 | 1.00 | HDAC1 (0.82) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL9492328 | 1.00 | HDAC1 (0.82) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL9492235 | 1.00 | HDAC1 (0.82) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL7460068 | 1.00 | HDAC1 (0.82) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL8779817 | 0.98 | HDAC1 (0.79) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL9491686 | 0.93 | NPC1 (0.75) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL9321669 | 0.92 | HDAC1 (0.72) | HDAC1HDAC2HDAC8HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11311624-B2 | Inhibitors of MEK/PI3K, JAK/MEK, JAK/PI3K/mTOR and MEK/PI3K/mTOR biological pathways and methods for improving lymphatic uptake, bioavailability, and solubility of therapeutic compounds | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-04-26 | — | — | US | disclosed |
| US-20200164081-A1 | INHIBITORS OF MEK/PI3K, JAK/MEK, JAK/PI3K/mTOR AND MEK/PI3K/mTOR BIOLOGICAL PATHWAYS AND METHODS FOR IMPROVING LYMPHATIC UPTAKE, BIOAVAILABILITY, AND SOLUBILITY OF THERAPEUTIC COMPOUNDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-05-28 | — | — | US | disclosed |
| WO-2019032640-A1 | INHIBITORS OF MEK/PI3K, JAK/MEK, JAK/PI3K/MTOR AND MEK/PI3K/MTOR BIOLOGICAL PATHWAYS AND METHODS FOR IMPROVING LYMPHATIC UPTAKE, BIOAVAILABILITY, AND SOLUBILITY OF THERAPEUTIC COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11311624-B2 | Inhibitors of MEK/PI3K, JAK/MEK, JAK/PI3K/mTOR and MEK/PI3K/mTOR biological pathways and methods for improving lymphatic uptake, bioavailability, and solubility of therapeutic compounds | MTOR, JAK2, JAK1 | HDAC1 740/4885HDAC2 1342/4885HDAC8 930/4885 |
| US-20200164081-A1 | INHIBITORS OF MEK/PI3K, JAK/MEK, JAK/PI3K/mTOR AND MEK/PI3K/mTOR BIOLOGICAL PATHWAYS AND METHODS FOR IMPROVING LYMPHATIC UPTAKE, BIOAVAILABILITY, AND SOLUBILITY OF THERAPEUTIC COMPOUNDS | MTOR, JAK2, JAK1 | HDAC1 740/4885HDAC2 1342/4885HDAC8 930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.