Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.71 |
| ▸ | RAF1 | P04049 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1232289 | 0.83 | MAPK14 (1.00) | MAPK14RAF1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9375869 | 0.82 | MAPK14 (0.49) | MAPK14RAF1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1234146 | 0.82 | MAPK14 (0.64) | MAPK14RAF1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1232255 | 0.82 | MAPK14 (0.81) | MAPK14RAF1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2074236 | 0.81 | MAPK14 (0.78) | MAPK14RAF1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2074239 | 0.81 | MAPK14 (0.78) | MAPK14RAF1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1233836 | 0.81 | MAPK14 (0.82) | MAPK14RAF1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2076214 | 0.79 | MAPK14 (1.00) | MAPK14RAF1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2073330 | 0.79 | MAPK14 (0.69) | MAPK14RAF1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1232243 | 0.79 | MAPK14 (0.77) | MAPK14RAF1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009124692-A1 | NEW SUBSTITUTED SPIRO[CYCLOALKYL-1,3'-INDOL]-2'(1'H)-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS. | ALMIRALL, S.A. (ES) | 2009-10-15 | — | — | WO | disclosed |
| EP-2108641-A1 | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors | Laboratorios Almirall, S.A. (ES) | 2009-10-14 | — | — | EP | disclosed |