Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 5/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20269069 | 0.86 | PGR (0.55) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21904076 | 0.85 | MAPK14 (0.44) | MAPK14CA9PGR | |
| SCHEMBL21904332 | 0.85 | MAPK14 (0.52) | MAPK14CA9RAF1 | |
| SCHEMBL12598497 | 0.85 | PGR (0.56) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16830171 | 0.83 | PGR (0.55) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13645447 | 0.82 | MAPK14 (0.71) | MAPK14RAF1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL29384453 | 0.81 | MAPK14 (0.53) | MAPK14PGRRAF1CYP1A2CYP2C9 | |
| SCHEMBL5975458 | 0.81 | MAPK14 (0.53) | MAPK14PGRRAF1CYP1A2CYP2C9 | |
| SCHEMBL11641780 | 0.79 | PGR (0.58) | MAPK14PGR | |
| SCHEMBL1971453 | 0.79 | TNKS (0.52) | MAPK14PGRCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344634-B1 | Bicyclic carboxamides, process for their preparation and medicaments containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-03-30 | — | — | EP | disclosed |
| US-5019587-A | Anticoagulants | BOEHRINGER MANNHEIM GMBH (DE) | 1991-05-28 | — | — | US | disclosed |
| EP-0344634-A1 | Bicyclic carboxamides, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1989-12-06 | — | — | EP | disclosed |
| EP-0216165-B1 | BENZODIPYRROLES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1989-11-23 | — | — | EP | disclosed |
| US-4874756-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-10-17 | — | — | US | disclosed |
| US-4835280-A | Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| US-4810801-A | Pyrrolobenzimidazoles, pharmaceutical compositions containing them, and use of them to treat certain heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1989-03-07 | — | — | US | disclosed |
| EP-0216165-A1 | Benzodipyrroles, processes for their preparation and pharmaceutical compositions containing these compounds | Roche Diagnostics GmbH (DE) | 1987-04-01 | — | — | EP | disclosed |