Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | GPR183 | P32249 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3153203 | 0.89 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL13373550 | 0.87 | HPGD (0.58) | SMN1; SMN2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL1063453 | 0.86 | L3MBTL1 (0.57) | SMN1; SMN2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL1855882 | 0.86 | HPGD (0.61) | SMN1; SMN2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL1855879 | 0.86 | HPGD (0.61) | SMN1; SMN2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL29565081 | 0.86 | HPGD (0.61) | SMN1; SMN2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL14559800 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL1063794 | 0.85 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL14559795 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL1065578 | 0.85 | L3MBTL1 (0.59) | SMN1; SMN2ALDH1A1KDM4EPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |