Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 13/20 | 0.64 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | OXTR | P30559 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3389775 | 0.85 | HRH3 (0.50) | HRH4HRH3OXTR | |
| SCHEMBL20449044 | 0.80 | HPGD (0.87) | HPGDTSHRMEN1KMT2APOLB | |
| SCHEMBL3039407 | 0.79 | MAPK14 (0.64) | HRH4KDRHPGDTSHRMEN1 | |
| SCHEMBL8262960 | 0.78 | MEN1 (0.60) | HRH4KDRHPGDTSHRHRH3 | |
| SCHEMBL6489709 | 0.77 | KDR (0.59) | HRH4KDRHPGDTSHRHRH3 | |
| SCHEMBL17468532 | 0.76 | HRH4 (0.62) | HRH4KDRHPGDTSHRHRH3 | |
| SCHEMBL5078878 | 0.75 | KDR (1.00) | HRH4KDRHPGDTSHR | |
| SCHEMBL13290547 | 0.75 | GPR183 (0.61) | HRH4KDRHPGDTSHRHRH3 | |
| SCHEMBL601515 | 0.75 | HRH4 (1.00) | HRH4HRH3HRH1MEN1KMT2A | |
| SCHEMBL4548025 | 0.75 | TSHR (1.00) | KDRHPGDTSHRHRH3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |