Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 15/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16199251 | 0.84 | NR1H2 (0.38) | NR1H2NR1H3 | |
| SCHEMBL15040570 | 0.80 | NR1H2 (0.49) | KDM4ENR1H2NR1H3ALDH1A1HPGD | |
| SCHEMBL10173695 | 0.80 | NR1H2 (0.49) | NR1H2NR1H3 | |
| SCHEMBL18966700 | 0.79 | ESR2 (0.43) | KDM4ENR1H2NR1H3ALDH1A1 | |
| SCHEMBL3835028 | 0.79 | MAPT (0.43) | MAPTKDM4ENPC1RAB9ANR1H2 | |
| SCHEMBL4389624 | 0.78 | AKR1C3 (0.49) | NR1H2NR1H3L3MBTL1 | |
| SCHEMBL1621434 | 0.78 | NR1H2 (0.43) | NR1H2NR1H3 | |
| SCHEMBL5436506 | 0.78 | NR1H2 (0.44) | NR1H2NR1H3 | |
| SCHEMBL13291550 | 0.78 | NR1H2 (0.44) | KDM4ENR1H2NR1H3 | |
| SCHEMBL5839140 | 0.76 | AKR1C3 (0.42) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |