Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | HCK | P08631 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.42 |
| ▸ | PRKDC | P78527 | 2/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10117911 | 0.83 | PIK3CD (0.43) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL4929175 | 0.81 | EP300 (0.56) | MAPTKDM4ENPC1RAB9APIK3CD | |
| SCHEMBL5482233 | 0.81 | HTR6 (0.41) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL12043978 | 0.80 | PIK3CD (0.44) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL3834470 | 0.80 | PIK3CD (0.41) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL819797 | 0.80 | PIK3CD (0.46) | KDM4EPIK3CDABL1EGFRHCK | |
| SCHEMBL18805035 | 0.80 | PIK3CD (0.46) | KDM4EPIK3CDABL1EGFRHCK | |
| SCHEMBL13646772 | 0.79 | MAPT (0.39) | MAPTKDM4ENPC1RAB9AMAOB | |
| SCHEMBL1273077 | 0.78 | HTR6 (0.49) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL3269495 | 0.78 | PIK3CD (0.47) | PIK3CDABL1EGFRHCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |