Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 8/20 | 0.39 |
| ▸ | JAK3 | P52333 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 3/20 | 0.36 |
| ▸ | CHUK | O15111 | 3/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13648049 | 0.85 | SCN9A (0.40) | MAPK10TP53CYP1A2CYP3A4LMNA | |
| SCHEMBL13648053 | 0.84 | EED (0.36) | MAPK8MAPK10IKBKBWEE1 | |
| SCHEMBL14489538 | 0.83 | TAAR1 (0.44) | MAPK10JAK3MAPK1ALDH1A1ALOX15 | |
| SCHEMBL13648065 | 0.82 | APOBEC3A (0.42) | SMN1; SMN2JAK2JAK3MAPK1ALDH1A1 | |
| SCHEMBL13648066 | 0.81 | SLC2A1 (0.41) | ALDH1A1WEE1 | |
| SCHEMBL13647859 | 0.71 | CDC7 (0.39) | MAPK10CYP1A2CYP3A4LMNACYP2C9 | |
| SCHEMBL13647850 | 0.70 | POLB (0.39) | MAPK10JAK3MAPK1ALDH1A1IKBKB | |
| SCHEMBL13513952 | 0.70 | SYK (0.36) | MAPK10JAK3MAPK1ALDH1A1IKBKB | |
| SCHEMBL13647855 | 0.70 | TNK2 (0.36) | MAPK10JAK3MAPK1WEE1 | |
| SCHEMBL13513928 | 0.69 | GSK3B (0.36) | MAPK8MAPK10TP53CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598245-B2 | Aminotriazole compounds useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-10-06 | — | — | US | disclosed |
| US-7226920-B2 | Aminotriazole compounds useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INC. (US) | 2007-06-05 | — | — | US | disclosed |