Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 6/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13648066 | 0.89 | SLC2A1 (0.41) | ALDH1A1SLC2A1 | |
| SCHEMBL13648049 | 0.85 | SCN9A (0.40) | L3MBTL1JAK2JAK3KITAURKA | |
| SCHEMBL13648053 | 0.84 | EED (0.36) | AURKASYK | |
| SCHEMBL14489538 | 0.83 | TAAR1 (0.44) | JAK3KITAURKAPOLBALDH1A1 | |
| SCHEMBL13648061 | 0.82 | MAPK8 (0.41) | JAK2JAK3ALDH1A1ALOX15MAPK1 | |
| SCHEMBL13647850 | 0.72 | POLB (0.39) | JAK3KITAURKAPOLBALDH1A1 | |
| SCHEMBL13647894 | 0.72 | WNT3A (0.39) | JAK2JAK3KITFLT3SYK | |
| SCHEMBL2856198 | 0.72 | WNT3A (0.39) | JAK2JAK3KITFLT3SYK | |
| SCHEMBL13647859 | 0.71 | CDC7 (0.39) | JAK3ALOX15SMN1; SMN2MAPT | |
| SCHEMBL20242761 | 0.71 | MAP3K5 (0.53) | L3MBTL1JAK2KITFLT3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598245-B2 | Aminotriazole compounds useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-10-06 | — | — | US | disclosed |
| US-7226920-B2 | Aminotriazole compounds useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INC. (US) | 2007-06-05 | — | — | US | disclosed |