Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 3/20 | 0.61 |
| ▸ | RAF1 | P04049 | 8/20 | 0.56 |
| ▸ | RET | P07949 | 4/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ABL1 | P00519 | 3/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.47 |
| ▸ | PLK4 | O00444 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 2/20 | 0.47 |
| ▸ | LYN | P07948 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13648245 | 0.88 | RET (0.53) | DDR2RAF1RETKDRGRM5 | |
| SCHEMBL13648247 | 0.88 | RET (0.53) | DDR2RAF1RETKDRGRM5 | |
| SCHEMBL13648264 | 0.88 | DDR2 (0.66) | DDR2RAF1RETKDRBRAF | |
| SCHEMBL13648290 | 0.88 | DDR2 (0.64) | DDR2RAF1RETKDRBRAF | |
| SCHEMBL13648241 | 0.87 | RAF1 (0.74) | DDR2RAF1RETKDRBRAF | |
| SCHEMBL13648339 | 0.86 | DDR2 (0.66) | DDR2RAF1RETKDRBRAF | |
| SCHEMBL5420554 | 0.84 | DDR2 (0.61) | DDR2RAF1RETKDRGRM5 | |
| SCHEMBL1662323 | 0.84 | RAF1 (0.75) | DDR2RAF1RETKDRBRAF | |
| SCHEMBL1660111 | 0.81 | DDR2 (0.64) | DDR2RAF1RETKDRBRAF | |
| SCHEMBL15574169 | 0.80 | DDR2 (0.82) | DDR2RAF1RETKDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090253688-A1 | Semicarbazide derivatives as kinase inhibitors | MERCK PATENT GMBH (DE) | 2009-10-08 | — | — | US | disclosed |
| US-20090253688-A1 | Semicarbazide derivatives as kinase inhibitors | MERCK PATENT GMBH (DE) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253688-A1 | Semicarbazide derivatives as kinase inhibitors | MAP3K1, MAP3K6, MAP3K2 | DDR2 629/4885RAF1 125/4885RET 117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.