Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 20/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12642605 | 1.00 | LTA4H (0.70) | LTA4HKCNH2 | |
| SCHEMBL12642599 | 0.91 | LTA4H (0.71) | LTA4HKCNH2 | |
| SCHEMBL12356637 | 0.83 | LTA4H (1.00) | LTA4HKCNH2 | |
| SCHEMBL12356634 | 0.83 | LTA4H (1.00) | LTA4HKCNH2 | |
| SCHEMBL1890793 | 0.83 | LTA4H (1.00) | LTA4HKCNH2 | |
| SCHEMBL13844786 | 0.79 | LTA4H (0.44) | LTA4HKCNH2 | |
| SCHEMBL12642598 | 0.78 | LTA4H (0.50) | LTA4H | |
| SCHEMBL12244452 | 0.77 | LTA4H (0.73) | LTA4HKCNH2 | |
| SCHEMBL1898474 | 0.77 | LTA4H (1.00) | LTA4HKCNH2 | |
| SCHEMBL1007663 | 0.77 | LTA4H (1.00) | LTA4HKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009126806-A2 | THIAZOLOPYRIDIN-2-YLOXY-PHENYL AND THIAZOLOPYRAZIN-2-YLOXY-PHENYL AMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | JANSSEN PHARMACEUTICA NV (BE) | 2009-10-15 | — | — | WO | disclosed |