Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 3/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.33 |
| ▸ | PGR | P06401 | 6/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2076566 | 0.76 | MAPK14 (0.41) | MAPK14RAF1MAP3K11PDE4APDE4B | |
| SCHEMBL25093213 | 0.73 | MAPK14 (0.39) | MAPK14RAF1MAP3K11PDE4APDE4B | |
| SCHEMBL13650344 | 0.73 | MAPK14 (0.45) | MAPK14RAF1PGR | |
| SCHEMBL17436172 | 0.71 | MAPK14 (0.37) | MAPK14RAF1PDE4APDE4BPDE4C | |
| SCHEMBL25093202 | 0.71 | MAPK14 (0.40) | MAPK14RAF1MAP3K11 | |
| SCHEMBL5976584 | 0.70 | MAPK14 (0.51) | MAPK14RAF1 | |
| SCHEMBL1224129 | 0.70 | MAPK14 (0.38) | MAPK14RAF1 | |
| SCHEMBL1223473 | 0.68 | MAPK14 (0.36) | MAPK14RAF1 | |
| SCHEMBL1223346 | 0.67 | MAPK14 (0.35) | MAPK14RAF1PDE4APDE4BPDE4C | |
| SCHEMBL25241582 | 0.66 | PGR (0.39) | MAPK14RAF1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009124692-A1 | NEW SUBSTITUTED SPIRO[CYCLOALKYL-1,3'-INDOL]-2'(1'H)-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS. | ALMIRALL, S.A. (ES) | 2009-10-15 | — | — | WO | disclosed |