Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.67 |
| ▸ | RAB9A | P51151 | 7/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.67 |
| ▸ | TP53 | P04637 | 5/20 | 0.67 |
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | TSHR | P16473 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | PKM | P14618 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.65 |
| ▸ | GFER | P55789 | 1/20 | 0.65 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.65 |
| ▸ | RELA | Q04206 | 1/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5553141 | 0.83 | SMN1; SMN2 (0.97) | MAPTSMN1; SMN2RAB9AKMT2ATP53 | |
| SCHEMBL12692391 | 0.79 | RAB9A (1.00) | MAPTSMN1; SMN2RAB9AKMT2ATP53 | |
| Dimethylamine SCHEMBL8559714 | 0.78 | SMN1; SMN2 (0.87) | MAPTSMN1; SMN2RAB9AKMT2ATP53 | |
| SCHEMBL13650865 | 0.78 | HDAC6 (0.76) | MAPTSMN1; SMN2RAB9AKMT2ATP53 | |
| SCHEMBL3627340 | 0.75 | HDAC6 (1.00) | MAPTSMN1; SMN2RAB9AKMT2ATP53 | |
| SCHEMBL5553186 | 0.75 | HDAC6 (0.76) | MAPTSMN1; SMN2RAB9AKMT2ATP53 | |
| SCHEMBL5550051 | 0.73 | HDAC6 (0.67) | MAPTSMN1; SMN2RAB9AKMT2ATP53 | |
| SCHEMBL11358348 | 0.73 | POLB (0.60) | MAPTSMN1; SMN2RAB9AKMT2ATP53 | |
| SCHEMBL8407047 | 0.72 | HDAC6 (0.74) | MAPTSMN1; SMN2RAB9AKMT2ATP53 | |
| SCHEMBL5550021 | 0.72 | HDAC6 (0.70) | MAPTSMN1; SMN2RAB9AKMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601846-B2 | Compounds having activity as inhibitors of apoptosis | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-10-13 | — | — | US | disclosed |