⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11281515 | 0.92 | — | — | |
| SCHEMBL98158 | 0.81 | — | — | |
| SCHEMBL20240530 | 0.81 | — | — | |
| SCHEMBL1132012 | 0.77 | — | — | |
| SCHEMBL935301 | 0.74 | — | — | |
| SCHEMBL21827323 | 0.74 | — | — | |
| SCHEMBL1998922 | 0.69 | — | — | |
| SCHEMBL27419310 | 0.67 | — | — | |
| SCHEMBL13330133 | 0.67 | — | — | |
| SCHEMBL23797204 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1936 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240226101-A1 | PYRIMIDINYLAMINOBENZENES FOR LUNG CANCER TREATMENT | SUZHOU PUHE BIOPHARMA CO LTD (CN) | 2024-07-11 | — | — | US | claimed |
| WO-2024145505-A1 | PYRIMIDINE CARBOXAMIDE COMPOUNDS | ACRIVON THERAPEUTICS, INC. (US) | 2024-07-04 | — | — | WO | claimed |
| EP-4373825-A1 | NITRILE SUMO INHIBITORS AND USES THEREOF | Suvalent Therapeutics, Inc. (US) | 2024-05-29 | — | — | EP | claimed |
| WO-2024094064-A1 | PYRIMIDINYLAMINOBENZENES FOR TREATING LUNG CANCER WITH DISTANT METASTASIS | SUZHOU PUHE BIOPHARMA CO., LTD (CN) | 2024-05-10 | — | — | WO | claimed |
| EP-4330256-A1 | PYRIMIDINYLAMINOBENZENES FOR LUNG CANCER TREATMENT | Suzhou Puhe Biopharma Co., Ltd. (CN) | 2024-03-06 | — | — | EP | claimed |
| CN-117561254-A | Pyrimidinylaminobenzene for lung cancer treatment | 苏州浦合医药科技有限公司 | 2024-02-13 | — | — | CN | claimed |
| US-20240002395-A1 | COMPOUNDS AND THEIR USE FOR TREATING NEUROPATHIC PAIN | THE JOHNS HOPKINS UNIVERSITY | 2024-01-04 | — | — | US | claimed |
| US-20230416205-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | TENVIE THERAPEUTICS, INC. | 2023-12-28 | — | — | US | claimed |
| WO-2023194964-A1 | FUSED PYRIDAZINE DERIVATIVES AS NLRP3 INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-10-12 | — | — | WO | claimed |
| EP-4255893-A1 | COMPOUNDS AND THEIR USE FOR TREATING NEUROPATHIC PAIN | The Johns Hopkins University (US) | 2023-10-11 | — | — | EP | claimed |
| WO-1997005877-A1 | 2-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 1997-02-20 | — | — | WO | claimed |
| EP-0378111-B1 | Isoxazole derivatives having anti-serotonin activity, their preparation process and compositions containing them | ZAMBON SPA (IT) | 1994-06-01 | — | — | EP | claimed |
| US-5250517-A | Hypotensive and cardiotonic agents; cardiac insufficiency | HOFFMANN-LA ROCHE INC. (US) | 1993-10-05 | — | — | US | claimed |
| US-5240925-A | FUNGICIDAL 2-ARYL-2-CYANO-2-(HETEROCYCLYLALKYL)ETHYL-1,2,4-TRIAZOLES | ROHM AND HAAS COMPANY (US) | 1993-08-31 | — | — | US | claimed |
| EP-0529973-A1 | Fungicidal 2-aryl-2-cyano-2-(heterocyclylalkyl)ethyl-1,2,4-triazoles | ROHM AND HAAS COMPANY (US) | 1993-03-03 | — | — | EP | claimed |
| EP-0525123-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES. | UPJOHN CO (US) | 1993-02-03 | — | — | EP | claimed |
| WO-1991019707-A2 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES | THE UPJOHN COMPANY (US) | 1991-12-26 | — | — | WO | claimed |
| US-4988691-A | Analgesics, cardiovascular disorders, nervous system disorders | ZAMBON GROUP S.P.A. (IT) | 1991-01-29 | — | — | US | claimed |
| EP-0378111-A1 | Isoxazole derivatives having anti-serotonin activity, their preparation process and compositions containing them | ZAMBON GROUP S.p.A. (IT) | 1990-07-18 | — | — | EP | claimed |
| EP-0079740-B1 | ANTHRANILOYLOXYALKANOATES | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1985-11-13 | — | — | EP | claimed |