Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | MARK3 | P27448 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.52 |
| ▸ | CDK9 | P50750 | 2/20 | 0.52 |
| ▸ | STK4 | Q13043 | 2/20 | 0.52 |
| ▸ | STK3 | Q13188 | 2/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.52 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.52 |
| ▸ | STK16 | O75716 | 1/20 | 0.52 |
| ▸ | STK10 | O94804 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2612682 | 0.87 | CDK9 (0.68) | PLK4FGFR1MARK3FLT3AURKB | |
| SCHEMBL646306 | 0.79 | PLK4 (0.71) | PLK4FGFR1MARK3FLT3AURKB | |
| SCHEMBL647248 | 0.79 | JAK2 (0.50) | PLK4FGFR1MARK3FLT3AURKB | |
| SCHEMBL2125065 | 0.78 | BTK (0.72) | PLK4FGFR1MARK3FLT3AURKB | |
| SCHEMBL2612678 | 0.78 | BTK (0.76) | PLK4FGFR1MARK3FLT3AURKB | |
| SCHEMBL13803579 | 0.77 | PLK4 (0.73) | PLK4FGFR1MARK3FLT3AURKB | |
| SCHEMBL2121951 | 0.77 | ABL1 (0.65) | PLK4FGFR1MARK3FLT3AURKB | |
| SCHEMBL2122628 | 0.76 | PLK4 (0.70) | PLK4FGFR1MARK3FLT3AURKB | |
| SCHEMBL14547647 | 0.75 | MAP3K11 (0.45) | PLK4FGFR1MARK3FLT3AURKB | |
| SCHEMBL648262 | 0.75 | CDK9 (0.67) | PLK4FGFR1MARK3FLT3AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009129401-A1 | KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-22 | — | — | WO | disclosed |
| WO-2008045834-A2 | KINASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2008-04-17 | — | — | WO | disclosed |