Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 13/20 | 0.60 |
| ▸ | PPARA | Q07869 | 2/20 | 0.55 |
| ▸ | CTSK | P43235 | 11/20 | 0.54 |
| ▸ | CTSB | P07858 | 4/20 | 0.53 |
| ▸ | CTSL | P07711 | 2/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1365337 | 1.00 | CTSS (0.60) | CTSSPPARACTSKCTSBCTSL | |
| SCHEMBL15341687 | 0.86 | SYK (0.62) | CTSSPPARACTSKCTSBCTSL | |
| SCHEMBL35211707 | 0.86 | PPARA (0.59) | CTSSPPARACTSKCTSBCTSL | |
| SCHEMBL1569316 | 0.86 | PPARA (0.59) | CTSSPPARACTSKCTSBCTSL | |
| SCHEMBL1363391 | 0.86 | PPARA (0.59) | CTSSPPARACTSKCTSBCTSL | |
| SCHEMBL1568593 | 0.85 | PPARA (0.61) | CTSSPPARACTSKCTSBCTSL | |
| SCHEMBL9180253 | 0.83 | CTSS (0.66) | CTSSCTSKCTSBCTSLATM | |
| SCHEMBL5916336 | 0.83 | CTSS (0.66) | CTSSCTSKCTSBCTSLATM | |
| SCHEMBL2012232 | 0.83 | CTSS (0.66) | CTSSCTSKCTSBCTSLATM | |
| SCHEMBL6131621 | 0.83 | PPARA (0.56) | CTSSPPARACTSKCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8618123-B2 | Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-12-31 | — | — | US | disclosed |
| EP-2178882-B1 | BENZENESULFONYL-CHROMANE, THIOCHROMANE, TETRAHYDRONAPHTHALENE AND RELATED GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME (US) | 2013-04-17 | — | — | EP | disclosed |
| US-8067621-B2 | Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors | SCHERING CORPORATION (US) | 2011-11-29 | — | — | US | disclosed |
| US-20110110948-A1 | BENZENESULFONYL-CHROMANE, THIOCHROMANE, TETRAHYDRONAPHTHALENE AND RELATED GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2011-05-12 | — | — | US | disclosed |
| EP-1976843-A2 | CARBOCYCLIC AND HETEROCYCLIC ARYLSULFONES AS GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007084595-A2 | CARBOCYCLIC AND HETEROCYCLIC ARYLSULFONES AS GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2007-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110110948-A1 | BENZENESULFONYL-CHROMANE, THIOCHROMANE, TETRAHYDRONAPHTHALENE AND RELATED GAMMA SECRETASE INHIBITORS | BACE1, PSEN1, BACE2 | CTSS 93/4885PPARA 1097/4885CTSK 380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.