Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 18/20 | 0.79 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.79 |
| ▸ | MARK3 | P27448 | 4/20 | 0.75 |
| ▸ | ULK1 | O75385 | 3/20 | 0.75 |
| ▸ | ULK2 | Q8IYT8 | 3/20 | 0.75 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.75 |
| ▸ | MARK4 | Q96L34 | 2/20 | 0.75 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.75 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.75 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.75 |
| ▸ | SIK1 | P57059 | 1/20 | 0.75 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.75 |
| ▸ | MELK | Q14680 | 1/20 | 0.75 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.75 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.75 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.75 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.75 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.75 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.75 |
| ▸ | CDK2 | P24941 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13431829 | 0.92 | TBK1 (0.80) | TBK1PDPK1MARK3ULK1ULK2 | |
| SCHEMBL13432039 | 0.92 | TBK1 (0.80) | TBK1PDPK1MARK3ULK1ULK2 | |
| SCHEMBL3384222 | 0.91 | TBK1 (0.77) | TBK1PDPK1MARK3ULK1ULK2 | |
| SCHEMBL13431894 | 0.90 | TBK1 (0.81) | TBK1PDPK1MARK3ULK1ULK2 | |
| SCHEMBL13431887 | 0.89 | TBK1 (0.75) | TBK1PDPK1MARK3ULK1ULK2 | |
| SCHEMBL13431882 | 0.89 | TBK1 (0.72) | TBK1PDPK1MARK3ULK1ULK2 | |
| SCHEMBL3384531 | 0.89 | TBK1 (0.82) | TBK1PDPK1MARK3ULK1ULK2 | |
| SCHEMBL13431885 | 0.89 | TBK1 (0.88) | TBK1PDPK1MARK3ULK1ULK2 | |
| SCHEMBL13460110 | 0.88 | TBK1 (0.81) | TBK1PDPK1MARK3ULK1ULK2 | |
| SCHEMBL13431782 | 0.88 | TBK1 (1.00) | TBK1PDPK1MARK3ULK1ULK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009122180-A1 | PYRIMIDINE DERIVATIVES CAPABLE OF INHIBITING ONE OR MORE KINASES | MEDICAL RESEARCH COUNCIL (GB) | 2009-10-08 | — | — | WO | disclosed |