⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6426443 | 1.00 | — | — | |
| SCHEMBL1365395 | 1.00 | — | — | |
| SCHEMBL11278155 | 0.88 | HSD17B10 (0.61) | — | |
| SCHEMBL11278159 | 0.88 | HSD17B10 (0.61) | — | |
| SCHEMBL10765956 | 0.88 | ALDH1A1 (0.33) | — | |
| SCHEMBL2427541 | 0.74 | — | — | |
| SCHEMBL18556369 | 0.74 | HSD17B10 (0.41) | — | |
| SCHEMBL13178068 | 0.74 | — | — | |
| SCHEMBL2773697 | 0.74 | — | — | |
| SCHEMBL13971732 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235857-B1 | UNSATURATED HALIDE OR SULFONYL CHAIN TRANSFER AGENTS | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2001-05-22 | — | — | US | claimed |
| US-10226459-B2 | Aza spiro alkane derivatives as inhibitors of metalloproteases | INCYTE HOLDINGS CORPORATION (US) | 2019-03-12 | — | — | US | disclosed |
| US-20180153882-A1 | AZA Spiro Alkane Derivatives as Inhibitors of Metalloproteases | INCYTE CORPORATION | 2018-06-07 | — | — | US | disclosed |
| US-9801877-B2 | AZA spiro alkane derivatives as inhibitors of metalloproteases | INCYTE CORPORATION (US) | 2017-10-31 | — | — | US | disclosed |
| US-20170035751-A1 | AZA Spiro Alkane Derivatives as Inhibitors of Metalloproteases | INCYTE CORPORATION | 2017-02-09 | — | — | US | disclosed |
| US-9440958-B2 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | INCYTE CORPORATION (US) | 2016-09-13 | — | — | US | disclosed |
| US-9403775-B2 | AZA spiro alkane derivatives as inhibitors of metalloproteases | INCYTE CORPORATION (US) | 2016-08-02 | — | — | US | disclosed |
| EP-3020402-A1 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | Incyte Holdings Corporation (US) | 2016-05-18 | — | — | EP | disclosed |
| EP-1622569-B1 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | INCYTE CORP (US) | 2015-12-02 | — | — | EP | disclosed |
| US-20150025056-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION (US) | 2015-01-22 | — | — | US | disclosed |
| EP-0444127-A4 | PROCESS FOR PREPARING BIS-METHYLENE SPIROORTHOCARBONATE | — | 1991-11-13 | — | — | EP | disclosed |
| EP-0444127-A1 | PROCESS FOR PREPARING BIS-METHYLENE SPIROORTHOCARBONATE | EPOLIN, INC. (US) | 1991-09-04 | — | — | EP | disclosed |
| WO-1990005727-A1 | PROCESS FOR PREPARING BIS-METHYLENE SPIROORTHOCARBONATE | EPOLIN, INC. (US) | 1990-05-31 | — | — | WO | disclosed |
| US-4891436-A | MULTISTEP, FROM METHALLYL CHLORIDE | EPOLIN, INC. (US) | 1990-01-02 | — | — | US | disclosed |
| EP-0159508-B1 | PROCESS FOR THE PREPARATION OF DICHLOROISOBUTENES | HÜLS AKTIENGESELLSCHAFT (DE) | 1987-05-27 | — | — | EP | disclosed |
| US-4587367-A | CHLORINATION | HUELS AKTIENGESELLSCHAFT (DE) | 1986-05-06 | — | — | US | disclosed |
| US-4587367-A | CHLORINATION | HUELS AKTIENGESELLSCHAFT (DE) | 1986-05-06 | — | — | US | disclosed |
| EP-0159508-A2 | Process for the preparation of dichloroisobutenes | HÜLS AKTIENGESELLSCHAFT (DE) | 1985-10-30 | — | — | EP | disclosed |
| EP-0159508-A2 | Process for the preparation of dichloroisobutenes | HÜLS AKTIENGESELLSCHAFT (DE) | 1985-10-30 | — | — | EP | disclosed |
| US-4196151-A | Process for producing β,γ-unsaturated aldehyde | NIPPON OIL AND FATS CO., LTD. (JP) | 1980-04-01 | — | — | US | disclosed |