Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13655395 | 0.76 | PIK3CA (0.67) | PIK3CANOTUMPIK3CB | |
| SCHEMBL989463 | 0.71 | PIK3CA (0.54) | PIK3CANOTUMPIK3CDPIK3CBPIK3CG | |
| SCHEMBL989431 | 0.70 | PIK3CA (0.80) | PIK3CANOTUMPIK3CB | |
| SCHEMBL988574 | 0.70 | PIK3CA (0.53) | PIK3CANOTUMPIK3CB | |
| SCHEMBL1038682 | 0.70 | PIK3CA (0.66) | PIK3CANOTUMPIK3CB | |
| SCHEMBL12535008 | 0.70 | PIK3CA (0.66) | PIK3CANOTUMPIK3CB | |
| SCHEMBL989272 | 0.69 | PIK3CA (1.00) | PIK3CANOTUMPIK3CB | |
| SCHEMBL988898 | 0.68 | PIK3CA (0.53) | PIK3CANOTUMPIK3CB | |
| SCHEMBL15663453 | 0.68 | PIK3CA (0.49) | PIK3CANOTUMPIK3CDPIK3CBPIK3CG | |
| SCHEMBL989089 | 0.68 | PIK3CA (0.51) | PIK3CANOTUMPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |