Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | PTAFR | P25105 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989272 | 0.80 | PIK3CA (1.00) | PIK3CAPIK3CBNOTUM | |
| SCHEMBL989431 | 0.80 | PIK3CA (0.80) | PIK3CAPIK3CBNOTUM | |
| SCHEMBL1038682 | 0.79 | PIK3CA (0.66) | PIK3CAPIK3CBNOTUM | |
| SCHEMBL12535008 | 0.77 | PIK3CA (0.66) | PIK3CAPIK3CBNOTUM | |
| SCHEMBL13655289 | 0.76 | PIK3CA (0.52) | PIK3CAPIK3CBNOTUM | |
| SCHEMBL1041397 | 0.74 | PIK3CA (0.76) | PIK3CAPIK3CB | |
| SCHEMBL1040881 | 0.74 | PIK3CA (0.77) | PIK3CAPIK3CB | |
| SCHEMBL12534854 | 0.74 | PIK3CA (0.88) | PIK3CAPIK3CBNOTUM | |
| SCHEMBL990579 | 0.71 | PIK3CA (0.55) | PIK3CAPIK3CBNOTUM | |
| SCHEMBL989463 | 0.70 | PIK3CA (0.54) | PIK3CAPIK3CBNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |