Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.60 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1369412 | 0.99 | MEN1 (0.59) | MEN1KMT2ACASP3SENP8SENP7 | |
| SCHEMBL4120142 | 0.88 | BRAF (0.53) | MEN1KMT2ACASP3SENP8SENP7 | |
| Hydrochloric Acid SCHEMBL4518253 | 0.87 | BRAF (0.52) | MEN1KMT2ACASP3SENP8SENP7 | |
| SCHEMBL12143169 | 0.82 | CDK8 (0.54) | MEN1KMT2AL3MBTL1MAPTRAB9A | |
| SCHEMBL29429732 | 0.82 | KDR (0.63) | MAPTRAB9ANPC1BRAFROCK2 | |
| SCHEMBL4128043 | 0.82 | KDR (0.63) | MAPTRAB9ANPC1BRAFROCK2 | |
| SCHEMBL1365527 | 0.80 | TNIK (0.49) | MEN1KMT2ACASP3SENP8SENP7 | |
| Hydrochloric Acid SCHEMBL1369411 | 0.79 | TNIK (0.49) | MEN1KMT2ACASP3SENP8SENP7 | |
| SCHEMBL12143154 | 0.77 | KIT (0.59) | MEN1KMT2AL3MBTL1MAPTRAB9A | |
| SCHEMBL12143163 | 0.77 | PIK3CA (0.56) | BRAFROCK2PRKD3MAP4K4CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067599-B2 | Imidazo [4,5-B] pyridine and pyrrolo [2,3-B] pyridine protein kinase inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2011-11-29 | — | — | US | disclosed |