Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | KIT | P10721 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.53 |
| ▸ | MTOR | P42345 | 3/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 4/20 | 0.52 |
| ▸ | AXL | P30530 | 2/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.52 |
| ▸ | CDK1 | P06493 | 2/20 | 0.52 |
| ▸ | FES | P07332 | 2/20 | 0.52 |
| ▸ | ROS1 | P08922 | 2/20 | 0.52 |
| ▸ | FER | P16591 | 2/20 | 0.52 |
| ▸ | FLT4 | P35916 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29429732 | 1.00 | KDR (0.63) | KDRNPC1RAB9AMAPTKIT | |
| SCHEMBL1370773 | 0.89 | RAB9A (0.54) | KDRNPC1RAB9AMAPTKIT | |
| SCHEMBL12143169 | 0.89 | CDK8 (0.54) | KDRNPC1RAB9AMAPTKIT | |
| SCHEMBL17420246 | 0.87 | NPC1 (0.55) | KDRNPC1RAB9AMAPTKIT | |
| SCHEMBL2040710 | 0.87 | RAB9A (0.65) | NPC1RAB9AKITPIK3CAMTOR | |
| SCHEMBL1370776 | 0.86 | RIPK1 (0.65) | KDRNPC1RAB9AMAPTKIT | |
| SCHEMBL12143163 | 0.85 | PIK3CA (0.56) | KDRKITBRAFPIK3CAMTOR | |
| SCHEMBL12143154 | 0.85 | KIT (0.59) | KDRNPC1RAB9AMAPTKIT | |
| SCHEMBL1370777 | 0.84 | CDK8 (0.56) | KDRNPC1RAB9AMAPTKIT | |
| SCHEMBL17420229 | 0.84 | KDR (0.54) | KDRNPC1RAB9AMAPTKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064213-A1 | HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2009-06-03 | — | — | EP | claimed |
| WO-2008028617-A1 | HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-13 | — | — | WO | claimed |
| US-20090318428-A1 | HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | HOFFMANN-LA ROCHE, INC. | 2009-12-24 | — | — | US | disclosed |
| CN-101511828-A | Heteroaryl derivatives as protein kinase inhibitors | HOFFMANN LA ROCHE (CH) | 2009-08-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318428-A1 | HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | MAP3K5, MAP3K1, PRKACA | KDR 1193/4885NPC1 1424/4885RAB9A 991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.