Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.60 |
| ▸ | LOX | P28300 | 2/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14860569 | 0.86 | LOXL2 (0.58) | LOXL2LOXSLC6A4AAK1CYP3A4 | |
| SCHEMBL13655389 | 0.86 | LOXL2 (0.58) | LOXL2LOXSLC6A4AAK1CYP3A4 | |
| SCHEMBL12093674 | 0.80 | LOXL2 (0.62) | LOXL2LOXAAK1CYP3A4ACACB | |
| SCHEMBL21227109 | 0.79 | LOX (0.54) | LOXL2LOXAAK1ACACB | |
| SCHEMBL12093688 | 0.78 | LOXL2 (0.61) | LOXL2LOXAAK1ACACB | |
| SCHEMBL25357821 | 0.77 | LOX (0.55) | LOXL2LOXACACBNOS3NOS1 | |
| SCHEMBL31747001 | 0.77 | LOX (0.55) | LOXL2LOXACACBNOS3NOS1 | |
| SCHEMBL14861107 | 0.77 | LOX (0.55) | LOXL2LOXACACBNOS3NOS1 | |
| SCHEMBL805488 | 0.77 | LOXL2 (0.69) | LOXL2LOXACACBPIK3CAMTOR | |
| SCHEMBL17492 | 0.77 | LOXL2 (0.51) | LOXL2LOXACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1450750-B1 | USE OF 2-AMINO-4-PYRIDYLMETHYL-THIAZOLINE DERIVATIVES AS INHIBITORS OF INDUCIBLE NO-SYNTHASE | AVENTIS PHARMA SA (FR) | 2009-10-21 | — | — | EP | disclosed |