Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990974 | 0.88 | PIK3CA (0.59) | PIK3CAALDH1A1GAAL3MBTL1KDM4E | |
| SCHEMBL990292 | 0.87 | PIK3CA (0.61) | PIK3CAALDH1A1GAAL3MBTL1KDM4E | |
| SCHEMBL989557 | 0.86 | PIK3CA (0.57) | PIK3CAALDH1A1GAAL3MBTL1KDM4E | |
| SCHEMBL12535807 | 0.84 | PIK3CA (0.55) | PIK3CAALDH1A1GAAL3MBTL1KDM4E | |
| SCHEMBL12535808 | 0.84 | PIK3CA (0.55) | PIK3CAALDH1A1GAAL3MBTL1KDM4E | |
| SCHEMBL989422 | 0.84 | PIK3CA (0.55) | PIK3CAALDH1A1GAAL3MBTL1KDM4E | |
| SCHEMBL989458 | 0.84 | PIK3CA (0.62) | PIK3CAALDH1A1GAAL3MBTL1KDM4E | |
| SCHEMBL987960 | 0.84 | PIK3CA (0.62) | PIK3CAALDH1A1GAAL3MBTL1KDM4E | |
| SCHEMBL988504 | 0.84 | PIK3CA (0.69) | PIK3CAALDH1A1GAAL3MBTL1KDM4E | |
| SCHEMBL989618 | 0.83 | PIK3CA (0.64) | PIK3CAALDH1A1GAAL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |