Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 10/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20597326 | 0.85 | NOTUM (0.77) | NOTUMKDM4EALDH1A1HPGDGAA | |
| SCHEMBL988576 | 0.85 | NOTUM (0.56) | NOTUMKDM4EALDH1A1HPGDGAA | |
| SCHEMBL20597295 | 0.85 | NOTUM (0.77) | NOTUMKDM4EALDH1A1HPGDGAA | |
| SCHEMBL990557 | 0.83 | NOTUM (0.80) | NOTUMKDM4EALDH1A1HPGDGAA | |
| SCHEMBL988949 | 0.81 | PIK3CA (0.63) | NOTUMKDM4EALDH1A1HPGDGAA | |
| SCHEMBL13655403 | 0.79 | PIK3CA (0.70) | PIK3CAPIK3CB | |
| SCHEMBL13655350 | 0.79 | NOTUM (0.45) | NOTUMKDM4EGAAPIK3CAPIK3CB | |
| SCHEMBL12095162 | 0.78 | NOTUM (0.51) | NOTUMKDM4EALDH1A1HPGDGAA | |
| SCHEMBL13655306 | 0.77 | PIK3CA (0.67) | PIK3CAPIK3CB | |
| SCHEMBL20596964 | 0.77 | NOTUM (0.70) | NOTUMKDM4EALDH1A1GAAPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |