Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12836699 | 0.89 | NOTUM (0.45) | NOTUMPIK3CAPIK3CBMAPTKDM4E | |
| SCHEMBL988846 | 0.81 | NOTUM (0.62) | NOTUMPIK3CAPIK3CBMAPTKDM4E | |
| SCHEMBL12535860 | 0.80 | PIK3CA (0.52) | NOTUMPIK3CAPIK3CB | |
| SCHEMBL13655329 | 0.79 | NOTUM (0.60) | NOTUMPIK3CAPIK3CBKDM4EGAA | |
| SCHEMBL988650 | 0.76 | PIK3CA (0.43) | NOTUMPIK3CAPIK3CB | |
| SCHEMBL1484768 | 0.71 | PIK3CA (0.52) | NOTUMPIK3CAPIK3CB | |
| SCHEMBL379230 | 0.70 | PRKCI (0.56) | MAPTKDM4EGAADYRK1ARAB9A | |
| SCHEMBL29364809 | 0.70 | PRKCI (0.56) | MAPTKDM4EGAADYRK1ARAB9A | |
| SCHEMBL988463 | 0.70 | NOTUM (0.70) | NOTUMPIK3CAPIK3CBKDM4EGAA | |
| SCHEMBL1484735 | 0.69 | MAP3K14 (0.40) | NOTUMPIK3CAPIK3CBMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |