Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 17/20 | 0.62 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL70456 | 0.86 | MAOB (0.76) | MAOBADORA2BNPC1MAPTRAB9A | |
| SCHEMBL27822584 | 0.84 | MAOB (0.73) | MAOBADORA2BNPC1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL87683 | 0.84 | MAOB (0.73) | MAOBADORA2BNPC1MAPTRAB9A | |
| SCHEMBL8761733 | 0.83 | MAOB (0.61) | MAOBADORA2BNPC1MAPTRAB9A | |
| SCHEMBL7383281 | 0.82 | MAOB (0.56) | MAOBADORA2BNPC1MAPTRAB9A | |
| SCHEMBL6345667 | 0.81 | KMT2A (0.61) | MAOBADORA2BNPC1MAPTRAB9A | |
| SCHEMBL2301535 | 0.80 | MAOB (0.58) | MAOBADORA2BNPC1MAPTRAB9A | |
| SCHEMBL1299217 | 0.80 | MAOB (0.58) | MAOBADORA2BNPC1MAPTRAB9A | |
| SCHEMBL87682 | 0.80 | MAOB (0.58) | MAOBADORA2BNPC1MAPTRAB9A | |
| SCHEMBL11264479 | 0.79 | MAOB (0.53) | MAOBADORA2BNPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1381366-B9 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC AMIDOPIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2009-10-21 | — | — | EP | disclosed |
| EP-1381366-B1 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC AMIDOPIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2009-04-22 | — | — | EP | disclosed |