Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8761733 | 0.88 | MAOB (0.61) | KMT2ARAB9AL3MBTL1SMN1; SMN2MAOB | |
| SCHEMBL25567893 | 0.88 | MAOB (0.73) | KMT2ARAB9AL3MBTL1SMN1; SMN2MAOB | |
| SCHEMBL9594944 | 0.88 | NPC1 (0.60) | KMT2ARAB9AL3MBTL1SMN1; SMN2MAOB | |
| SCHEMBL11856874 | 0.86 | KMT2A (0.50) | KMT2ARAB9AL3MBTL1SMN1; SMN2MAOB | |
| SCHEMBL588963 | 0.82 | KMT2A (0.71) | KMT2ARAB9AL3MBTL1SMN1; SMN2MAOB | |
| SCHEMBL70456 | 0.82 | MAOB (0.76) | RAB9AMAOBALDH1A1HPGDHSD17B10 | |
| SCHEMBL289145 | 0.82 | SIRT1 (0.81) | KMT2ARAB9AL3MBTL1SMN1; SMN2MAOB | |
| SCHEMBL27822584 | 0.81 | MAOB (0.73) | RAB9AMAOBALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL87683 | 0.81 | MAOB (0.73) | RAB9AMAOBALDH1A1HPGDHSD17B10 | |
| SCHEMBL13655497 | 0.81 | MAOB (0.62) | RAB9AMAOBHPGDHSD17B10ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102370632-A | Application of SIRT1 micro-molecular inhibitor in preparation of medicines for treating or preventing caner and protein deacetylation related diseases | SHANGHAI INST MATERIA MEDICA | 2012-03-14 | — | — | CN | claimed |
| EP-0425359-B1 | Process for the preparation of 3-benzoyl-benzofuran derivatives | SANOFI SA (FR) | 1995-10-11 | — | — | EP | claimed |
| US-5266711-A | Process for the preparation of 3-benzoyl benzofuran derivatives | SANOFI (FR) | 1993-11-30 | — | — | US | claimed |
| CN-108484546-B | A kind of preparation method of 2- methyl -3- benzoyl benzofuran derivatives | 江南大学 | 2019-11-08 | — | — | CN | disclosed |
| CN-108484546-A | A kind of preparation method of 2- methyl -3- benzoyl benzofuran derivatives | 江南大学 | 2018-09-04 | — | — | CN | disclosed |
| US-9890132-B2 | Process for the preparation of anti-inflammatory aroylbenzofuran compounds | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2018-02-13 | — | — | US | disclosed |
| US-9890132-B2 | Process for the preparation of anti-inflammatory aroylbenzofuran compounds | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2018-02-13 | — | — | US | disclosed |
| US-20160229827-A1 | A PROCESS FOR THE PREPARATION OF ANTI-INFLAMMATORY AROYLBENZOFURAN COMPOUNDS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-08-11 | — | — | US | disclosed |
| CN-102370632-A | Application of SIRT1 micro-molecular inhibitor in preparation of medicines for treating or preventing caner and protein deacetylation related diseases | SHANGHAI INST MATERIA MEDICA | 2012-03-14 | — | — | CN | disclosed |
| US-6844358-B2 | Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia | WYETH (US) | 2005-01-18 | — | — | US | disclosed |
| US-20040102480-A1 | Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia | WYETH (US) | 2004-05-27 | — | — | US | disclosed |
| WO-1999058519-A1 | PHENYL OXO-ACETIC ACIDS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-18 | — | — | WO | disclosed |
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0425359-B1 | Process for the preparation of 3-benzoyl-benzofuran derivatives | SANOFI SA (FR) | 1995-10-11 | — | — | EP | disclosed |
| US-5266711-A | Process for the preparation of 3-benzoyl benzofuran derivatives | SANOFI (FR) | 1993-11-30 | — | — | US | disclosed |
| US-5266711-A | Process for the preparation of 3-benzoyl benzofuran derivatives | SANOFI (FR) | 1993-11-30 | — | — | US | disclosed |
| US-5266711-A | Process for the preparation of 3-benzoyl benzofuran derivatives | SANOFI (FR) | 1993-11-30 | — | — | US | disclosed |
| EP-0425359-A1 | Process for the preparation of 3-benzoyl-benzofuran derivatives | SANOFI (FR) | 1991-05-02 | — | — | EP | disclosed |
| EP-0425359-A1 | Process for the preparation of 3-benzoyl-benzofuran derivatives | SANOFI (FR) | 1991-05-02 | — | — | EP | disclosed |
| US-4766223-A | FROM ALKYL BENZOFURAN AND 4-METHOXYBENZOYL HALIDE; HYDROLYSIS, DEMETHYLATION | SANOFI (FR) | 1988-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229827-A1 | A PROCESS FOR THE PREPARATION OF ANTI-INFLAMMATORY AROYLBENZOFURAN COMPOUNDS | LITAF, IL1B, CYP2F1 | KMT2A 4215/4885RAB9A 4111/4885L3MBTL1 4485/4885 |
| US-20040102480-A1 | Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia | GPR119, INSR, GCKR | KMT2A 4051/4885RAB9A 2395/4885L3MBTL1 2169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.