Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 18/20 | 0.49 |
| ▸ | RAMP1 | O60894 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13772886 | 0.94 | CALCRL (0.52) | CALCRLRAMP1 | |
| SCHEMBL14044251 | 0.94 | CALCRL (0.51) | CALCRLRAMP1 | |
| SCHEMBL14044248 | 0.93 | CALCRL (0.52) | CALCRLRAMP1 | |
| SCHEMBL14017817 | 0.92 | CALCRL (0.55) | CALCRLRAMP1 | |
| SCHEMBL13655714 | 0.91 | CALCRL (0.49) | CALCRLRAMP1 | |
| SCHEMBL14016552 | 0.90 | CALCRL (0.49) | CALCRLRAMP1 | |
| SCHEMBL14044249 | 0.90 | CALCRL (0.52) | CALCRLRAMP1 | |
| SCHEMBL13772873 | 0.90 | CALCRL (0.50) | CALCRLRAMP1 | |
| SCHEMBL13655848 | 0.90 | CALCRL (0.49) | CALCRLRAMP1KDM4E | |
| SCHEMBL14016560 | 0.89 | CALCRL (0.50) | CALCRLRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108648-A1 | Selected CGRP antagonists, method for their manufacture and use as medicines | Boehringer Ingelheim International GmbH (DE) | 2009-10-14 | — | — | EP | disclosed |
| EP-1863791-B1 | 2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-YL-PIPERIDINES USED AS CGRP ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2008-11-12 | — | — | EP | disclosed |