Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13656227 | 0.85 | GRIN1 (0.49) | HTR7GRIN1GRIN2BMAPTSMN1; SMN2 | |
| SCHEMBL12575490 | 0.82 | SIGMAR1 (0.53) | HTR7SIGMAR1GRIN1GRIN2BDRD2 | |
| SCHEMBL13656110 | 0.81 | GRIN1 (0.67) | GRIN1GRIN2BMAPTSMN1; SMN2RAB9A | |
| SCHEMBL13656297 | 0.81 | GRIN1 (0.67) | GRIN1GRIN2BDRD2DRD3HTR2A | |
| SCHEMBL2020033 | 0.78 | GRIN1 (0.68) | HTR7SIGMAR1GRIN1GRIN2BHTR1A | |
| SCHEMBL13656118 | 0.74 | GRIN1 (0.69) | GRIN1GRIN2BMAPTSMN1; SMN2RAB9A | |
| SCHEMBL13656229 | 0.72 | GRIN1 (0.51) | HTR7GRIN1GRIN2BMAPTSMN1; SMN2 | |
| SCHEMBL13656270 | 0.71 | GRIN1 (0.60) | SIGMAR1GRIN1GRIN2BDRD2DRD3 | |
| SCHEMBL28161148 | 0.71 | BCL2A1 (0.67) | HTR7SIGMAR1DRD2DRD3MAPT | |
| SCHEMBL11938912 | 0.70 | KDM4E (0.68) | HTR7SIGMAR1DRD2HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420680-B2 | NMDA receptor antagonists for neuroprotection | EMORY UNIVERSITY (US) | 2013-04-16 | — | — | US | disclosed |
| US-20090253710-A1 | NMDA Receptor Antagonists for Neuroprotection | EMORY UNIVERSITY | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253710-A1 | NMDA Receptor Antagonists for Neuroprotection | GRIN1, GRIN2C, GRIK1 | HTR7 443/4885SIGMAR1 155/4885GRIN1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.