Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17071901 | 1.00 | CTSS (0.40) | CTSSCTSKGAATSHRUSP2 | |
| SCHEMBL19198363 | 1.00 | CTSS (0.40) | CTSSCTSKGAATSHRUSP2 | |
| SCHEMBL18964373 | 0.85 | GAA (0.36) | CTSSCTSKGAATSHRUSP2 | |
| SCHEMBL14712238 | 0.83 | GAA (0.36) | CTSSCTSKGAATSHRUSP2 | |
| SCHEMBL24595157 | 0.83 | CTSS (0.40) | CTSSCTSKGAATSHRPSEN1 | |
| SCHEMBL15354736 | 0.83 | GAA (0.37) | GAATSHRUSP2HSD17B10CA1 | |
| SCHEMBL10093672 | 0.83 | GAA (0.37) | GAATSHRUSP2HSD17B10CA1 | |
| SCHEMBL11404 | 0.82 | CTSS (0.42) | CTSSCTSKGAAPSEN1PSEN2 | |
| SCHEMBL12975647 | 0.81 | PIK3CD (0.38) | CTSSCTSKGAATSHRUSP2 | |
| SCHEMBL28121984 | 0.81 | CTSS (0.39) | CTSSCTSKGAAPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106432311-A | Processes and intermediates for producing azaindoles | 沃泰克斯药物股份有限公司 | 2017-02-22 | — | — | CN | disclosed |
| EP-1973911-B1 | AZAINDOLES USEFUL FOR THE TREATMENT OF (INTER ALIA) PROLIFERATIVE, CARDIAC, NEURODEGENERATIVE, AUTOIMMUNE OR INFLAMMATORY DISORDERS | VERTEX PHARMA (US) | 2016-01-13 | — | — | EP | disclosed |
| WO-2015027005-A1 | ISOTOPICALLY ENRICHED AZAINDOLES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-02-26 | — | — | WO | disclosed |
| EP-2763535-A1 | AZAINDOLES AS JANUS KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013052355-A1 | AZAINDOLES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-04-11 | — | — | WO | disclosed |
| EP-2559694-A2 | Azaindoles useful as inhibitors of Janus kinases | Vertex Pharmaceuticals, Inc. (US) | 2013-02-20 | — | — | EP | disclosed |
| EP-2537849-A2 | Azaindoles useful as inhibitors of janus kinases | Vertex Pharmaceuticals, Inc. (US) | 2012-12-26 | — | — | EP | disclosed |
| US-20090246481-A1 | DISPERSION OF WATER-INSOLUBLE COLORANT, METHOD OF PRODUCING SUBSTANCE CONTAINING WATER-INSOLUBLE COLORANT, FINE PARTICLES OF WATER-INSOLUBLE COLORANT, DISPERSING AGENT FOR WATER-INSOLUBLE COLORANT, AND RECORDING LIQUID, INK SET, PRINTED ARTICLE, METHOD OF FORMING IMAGE AND IMAGE FORMING APPARATUS USING THE SAME | FUJIFILM CORPORATION (JP) | 2009-10-01 | — | — | US | disclosed |
| WO-2007084557-A2 | AZAINDOLES USEFUL AS INHIBITORS OF JANUS KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-07-26 | — | — | WO | disclosed |