Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13656181 | 0.98 | CYP2D6 (0.33) | CYP2D6HTR1ACYP1A2ALOX15ADRA1B | |
| SCHEMBL19962321 | 0.94 | CYP1A2 (0.32) | CYP2D6HTR1ACYP1A2ALOX15ADRA1B | |
| SCHEMBL26455588 | 0.93 | CYP2D6 (0.37) | CYP2D6CYP1A2ALOX15SMN1; SMN2 | |
| SCHEMBL24842172 | 0.91 | CYP2D6 (0.36) | CYP2D6CYP1A2ALOX15SMN1; SMN2 | |
| SCHEMBL19962318 | 0.85 | HSD11B1 (0.36) | CYP2D6CYP1A2 | |
| SCHEMBL12228922 | 0.84 | CYP2D6 (0.37) | CYP2D6CYP1A2ALOX15SMN1; SMN2 | |
| SCHEMBL23594395 | 0.83 | GRIN2D (0.36) | CYP2D6CYP1A2ALOX15SMN1; SMN2 | |
| SCHEMBL26455582 | 0.82 | TSHR (0.36) | CYP2D6CYP1A2ALOX15 | |
| SCHEMBL23075935 | 0.81 | CYP1A2 (0.45) | CYP2D6CYP1A2ALOX15 | |
| SCHEMBL10201616 | 0.81 | TSHR (0.46) | CYP2D6CYP1A2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605176-B2 | β-ketoamide compounds with MCH antagonistic activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-20 | — | — | US | disclosed |
| US-7592373-B2 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-22 | — | — | US | disclosed |
| US-7592373-B2 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-22 | — | — | US | disclosed |