Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.73 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.73 |
| ▸ | HTR2A | P28223 | 6/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4009683 | 0.84 | MCHR1 (1.00) | MCHR1CHRM1HTR2ACYP2D6ACHE | |
| SCHEMBL3861539 | 0.83 | MCHR1 (0.98) | MCHR1CHRM1HTR2ACYP2D6ACHE | |
| SCHEMBL3879260 | 0.83 | MCHR1 (0.98) | MCHR1CHRM1HTR2ACYP2D6ACHE | |
| SCHEMBL28663251 | 0.82 | RAB9A (0.76) | MCHR1CHRM1HTR2ACYP2D6KMT2A | |
| SCHEMBL22079996 | 0.82 | RAB9A (0.76) | MCHR1CHRM1HTR2ACYP2D6KMT2A | |
| SCHEMBL4014334 | 0.81 | CHRM1 (1.00) | MCHR1CHRM1HTR2AACHEKMT2A | |
| SCHEMBL3869105 | 0.80 | MCHR1 (0.67) | MCHR1CHRM1HTR2ACYP2D6KDM4E | |
| SCHEMBL3869109 | 0.80 | MCHR1 (0.67) | MCHR1CHRM1HTR2ACYP2D6KDM4E | |
| SCHEMBL3869111 | 0.80 | MCHR1 (0.67) | MCHR1CHRM1HTR2ACYP2D6KDM4E | |
| SCHEMBL3869748 | 0.80 | CHRM1 (0.98) | MCHR1CHRM1HTR2AACHEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605176-B2 | β-ketoamide compounds with MCH antagonistic activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-20 | — | — | US | disclosed |
| US-7605176-B2 | β-ketoamide compounds with MCH antagonistic activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-20 | — | — | US | disclosed |