Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ME2 | P23368 | 1/20 | 0.45 |
| ▸ | ME1 | P48163 | 1/20 | 0.45 |
| ▸ | ME3 | Q16798 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13656118 | 0.86 | GRIN1 (0.69) | MAPTGRIN1GRIN2BMAPK1TSHR | |
| SCHEMBL12575993 | 0.86 | GRIN1 (0.57) | MAPTGRIN1GRIN2BMAPK1TSHR | |
| SCHEMBL13656113 | 0.85 | GRIN1 (0.49) | MAPTGRIN1GRIN2BMEN1KMT2A | |
| SCHEMBL2018858 | 0.82 | GRIN1 (0.75) | MAPTGRIN1GRIN2BMAPK1TSHR | |
| SCHEMBL8008461 | 0.82 | GRIN1 (0.52) | MAPTGRIN1GRIN2BMAPK1TSHR | |
| SCHEMBL8007017 | 0.80 | MAPT (0.53) | MAPTGRIN1GRIN2BMAPK1TSHR | |
| SCHEMBL7999240 | 0.73 | DRD2 (0.50) | MAPTENPP2MEN1KMT2ALMNA | |
| SCHEMBL13656202 | 0.72 | GRIN1 (0.49) | GRIN1GRIN2BTSHRMEN1KMT2A | |
| SCHEMBL13656110 | 0.72 | GRIN1 (0.67) | MAPTGRIN1GRIN2BMAPK1MEN1 | |
| SCHEMBL12575492 | 0.71 | GRIN1 (0.77) | MAPTGRIN1GRIN2BMAPK1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420680-B2 | NMDA receptor antagonists for neuroprotection | EMORY UNIVERSITY (US) | 2013-04-16 | — | — | US | disclosed |
| US-20090253710-A1 | NMDA Receptor Antagonists for Neuroprotection | EMORY UNIVERSITY | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253710-A1 | NMDA Receptor Antagonists for Neuroprotection | GRIN1, GRIN2C, GRIK1 | MAPT 2477/4885GRIN1 1/4885GRIN2B 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.