Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.67 |
| ▸ | HDAC10 | Q969S8 | 12/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.67 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.67 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.67 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.67 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.67 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.67 |
| ▸ | DRD2 | P14416 | 3/20 | 0.54 |
| ▸ | DRD3 | P35462 | 3/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | TNKS | O95271 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2639346 | 0.84 | MGAM (0.56) | HDAC1HDAC10HDAC6HDAC2HDAC3 | |
| SCHEMBL5020897 | 0.84 | HDAC3 (0.61) | HDAC1HDAC2HDAC3DRD2DRD3 | |
| SCHEMBL10242977 | 0.82 | HDAC3 (0.61) | HDAC1HDAC2HDAC3DRD2DRD3 | |
| SCHEMBL29222038 | 0.79 | HDAC3 (0.61) | HDAC1HDAC2HDAC3DRD2DRD3 | |
| SCHEMBL30858823 | 0.79 | HDAC3 (0.61) | HDAC1HDAC2HDAC3DRD2DRD3 | |
| SCHEMBL2639342 | 0.79 | PPARD (0.57) | HDAC1HDAC2HDAC3DRD2DRD3 | |
| SCHEMBL1937005 | 0.78 | HDAC1 (1.00) | HDAC1HDAC2HDAC3 | |
| SCHEMBL28408662 | 0.77 | HDAC6 (0.74) | HDAC1HDAC10HDAC6HDAC2HDAC3 | |
| SCHEMBL10207276 | 0.77 | HDAC1 (1.00) | HDAC1HDAC10HDAC6HDAC2HDAC3 | |
| SCHEMBL1364346 | 0.77 | HDAC1 (0.76) | HDAC1HDAC10HDAC6HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067600-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-8067600-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-8067600-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-7507828-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2009-03-24 | — | — | US | disclosed |
| US-7507828-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2009-03-24 | — | — | US | disclosed |