Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 17/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1043685 | 1.00 | KIF11 (0.59) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL1044036 | 0.95 | KIF11 (0.67) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL1043978 | 0.86 | KIF11 (0.49) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL12391890 | 0.85 | KIF11 (0.74) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5753590 | 0.84 | KIF11 (0.76) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5863987 | 0.83 | KIF11 (0.66) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL1041439 | 0.82 | KIF11 (0.81) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3494904 | 0.82 | KIF11 (0.81) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3496153 | 0.81 | KIF11 (0.80) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL3496152 | 0.81 | KIF11 (0.80) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608723-B2 | N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-1H-benzimidazol-2-yl)-2-methylpropyl]-4-chlorobenzamide;kinesin spindle protein modulators; anticarcinogenic agents; in vivo stability, bio-availability; diagnosis/medical/;antitumor agents hyperplasia; restinosis; antiinflammatory agents; cardiac hypertrophy | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2009-10-27 | — | — | US | disclosed |
| US-7608723-B2 | N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-1H-benzimidazol-2-yl)-2-methylpropyl]-4-chlorobenzamide;kinesin spindle protein modulators; anticarcinogenic agents; in vivo stability, bio-availability; diagnosis/medical/;antitumor agents hyperplasia; restinosis; antiinflammatory agents; cardiac hypertrophy | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2009-10-27 | — | — | US | disclosed |